Our vision is to contribute to understanding, preventing, and treating the major health problems of low- and middle-income countries (LMICs), through partnerships with academic institutions in Africa, Asia, and Latin America. We will integrate Imperial College London (ICL)'s expertise in Science, Engineering, Medicine, Public Health and Policy to study the health problems of global importance andbuild local research excellence. Collaborating teams will be supported to address major health problems of partner LMIC countries. Our Focus will be: 1.Mechanisms and population dynamics of tuberculosis (TB), HIV, HIV-TB, malaria,and neglected tropical diseases (NTDs). 2. Vaccine prevention and treatment of major childhood infections. 3. Non-communicable diseases (NCD's) including trends, risks and management of cardiometabolic conditions, chronic respiratory diseases, and selected cancers. 4. Integration of infection-NCD mechanisms and prevention including the role of infections and parasitic diseases on cancers and cardiovascular diseases; smoking and diabetes on TB susceptibility and progression; and the NCD consequences of long-term antiretroviral therapy. 5. Clinical trials. We will augment capacity in our partner institutions to design and conduct clinical trials by the formation ofa clinical studies group, to share training, expertise and advice on trial design, conduct and analysis. 6. Translational research in biotechnology, diagnostics, and environmental technologies. We will engage the considerable strengths in engineering at ICL and the Imperial College Institute of Global Health Innovation. We will foster the careers of a new generation of LMIC scholars. 1. We will establish a mentorship programme utilising the broad range of clinical and scientific expertise at ICL via the creation of a College of Mentors to support promising clinicians and non-clinical scientistsfrom LMIC during the preparation of research proposals and applications for independent support. 2. We will advance excellence in global health research in partner countries and institutions by coordinating training through exchange visits, short courses, workshops, and distance learning. 3. We will complement training of clinicians with that of basic scientists, public health researchers and engineers. 4. We will transferthe strength of ICL in clinical and epidemiological research methods, informatics, statistics, and computational biology to partners in LMICs via exchange visits, short courses, and workshops. 5. We will provide sabbatical support at ICL to senior academics in LMIC to learn new techniques or foster new collaborations, and encourage ICL academics to spend time at LMIC partner institutions. 6. We will foster south-south engagement through multi-centre collaborations, workshops, and exchange visits.