Cancer is one of the leading causes of mortality in the world. Many interventions have been developed to circumvent issues that were encountered in diagnosis, treatment and prevention, yet there is still the need for improvement. Thus, the goal of the project of 'Top International Research Center' is to combine existing strengths of both cancer centers in Taiwan, College of Medicine, National Taiwan University and China Medical University & Hospital, and MD Anderson Cancer Center, USA and to improve diagnosis, treatment and prevention for cancer patients in Taiwan. The research will be focused on discovering new biomarkers, molecular mechanisms of pathogenesis and metabolomics, signal transduction pathways of cancer cells and the role of cancer stem cells with the combination of drug discovery, development of novel targeted therapy and clinical trials.