Cardiovascular disease (CVD) and cancer are the leading cause of death in Canada and in Western society. When death is not the end point, they jeopardized the quality of life. CVD and cancer are also the leading cause of hospital admissions and despite progress in their prevention, detection, and treatment, which exact an enormous toll in Canada (billions of dollar each year); it will still kill thousand of Canadian this year. The important role of chronic inflammatory reaction in the development of atherosclerosis, cancer and other chronic diaseses like scleroderma makes inflammation an attractive target for the future treatment of these diseases. Since several proinflammatory cytokines are responsible for the onset and progression of these diseases, the proposed research program and infrastructure aim at understanding and demonstrating the role of two family of protein kinases involved in the production of many proinflammatory cytokines associated with cancer, atherosclerosis and autoimmune diseases development.