Radiotherapy is an important modality in curative management of locally advanced vulvar cancer. Radiotherapy is typically delivered in conjunction with chemotherapy and possibly surgery. Vulvar cancer is a relatively rare disease, however, and there is therefore very little knowledge about the pattern of loco regional failures after radiotherapy. This lack of knowledge represents a missed opportunity as it impedes rational risk/benefit assessments when prescribing the radiation. The optimal radiation dose prescription strategy is therefore disputed.
Here we propose a systematic analysis of all locoregional recurrences observed in the vulvar cancer patients treated in MD Anderson, Houston and Copenhagen since 2005. CT, MR or PET/CT scans of locoregional recurrences will be extracted from the picture archival systems (PACS) and the recurrence volume will be delineated based on all available clinical information.