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A Systematic and Detailed Analysis of Locoregional Pattern Failure in Vulvar Cancer- Towards Data Driven Radiation Dose Prescription

Anuja Jhingran

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University of Texas MD Anderson Cancer Center
Radiotherapy is an important modality in curative management of locally advanced vulvar cancer. Radiotherapy is typically delivered in conjunction with chemotherapy and possibly surgery. Vulvar cancer is a relatively rare disease, however, and there is therefore very little knowledge about the pattern of loco­ regional failures after radiotherapy. This lack of knowledge represents a missed opportunity as it impedes rational risk/benefit assessments when prescribing the radiation. The optimal radiation dose prescription strategy is therefore disputed. Here we propose a systematic analysis of all locoregional recurrences observed in the vulvar cancer patients treated in MD Anderson, Houston and Copenhagen since 2005. CT, MR or PET/CT scans of locoregional recurrences will be extracted from the picture archival systems (PACS) and the recurrence volume will be delineated based on all available clinical information.

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